An Orthotopic Model of Murine Bladder Cancer
نویسندگان
چکیده
منابع مشابه
An orthotopic model of murine bladder cancer.
In this straightforward procedure, bladder tumors are established in female C57 mice through the use of catheterization, local cauterization, and subsequent cell adhesion. After their bladders are transurethrally catheterized and drained, animals are again catheterized to permit insertion of a platinum wire into bladders without damaging the urethra or bladder. The catheters are made of Teflon ...
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Cigarette smoking (CS) is the main risk factor for bladder cancer development. There are more than 100 carcinogens present in cigarette smoke. Among the potential mediators of CS-induced alterations is nuclear factor-kappa (NF-kappaB), which is responsible for the transcription of genes related to cell transformation, tumor promotion, angiogenesis, invasion and metastasis. Curcumin is a polyphe...
متن کاملOptimizing syngeneic orthotopic murine bladder cancer (MB49).
The syngeneic orthotopic murine bladder cancer model MB49 is hampered by unreliable tumor implantation. We optimized this model by a simple modification of the standard implantation technique in three groups of mice. Fifty thousand (group I), 20,000 (group II), or 10,000 (group III) tumor cells were implanted into cauterized bladders by transurethral instillation, and dwell time was prolonged t...
متن کاملTumor Establishment Features of Orthotopic Murine Bladder Cancer Models
PURPOSE Animal tumor models are important for the evaluation of novel therapeutic modalities. Since the initial report of an orthotopic bladder tumor model, several modifications have been proposed to improve the tumor take rate. Here we compared the HCl-pretreated and electrocauterization-pretreated orthotopic murine bladder tumor models. MATERIALS AND METHODS MBT-2 murine bladder cancer cel...
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Disruptive TP53 Mutation is Associated with Aggressive Disease Characteristics in an 1 Orthotopic Murine Model of Oral Tongue Cancer 2 3 Daisuke Sano, Tong-Xin Xie, Thomas J. Ow, Mei Zhao, Curtis R. Pickering, Ge 4 Zhou, Vlad C. Sandulache, David A. Wheeler, Richard A. Gibbs, Carlos Caulin, and 5 Jeffrey N. Myers** 6 7 Department of Head and Neck Surgery, The University of Texas MD Anderson Can...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2011
ISSN: 1940-087X
DOI: 10.3791/2535